LASA*S00, LASA*S01, LASA*S02
Contact: D.S. Roos
With increasing age olfactory function declines . Olfactory function is, together with taste, important in food choice and intake, which might correlate with loss of weight . Also in various neurodegenerative disorders, like Parkinson’s disease, the prevalence of olfactory loss is higher than in healthy aging people . Moreover, an otherwise unexplained impairment of olfactory function is a risk factor for the development of Parkinson’s disease [4, 5].
Measurement instruments in LASA
To measure olfactory function a Dutch version of the University of Pennsylvania Smell Identification Test (UPSIT)  was used. This test consists of 40 odorized items. After scratching an odorized patch the person has to smell the odour and choose the correct one out of four items. Optimal discrimination criteria for various age groups and gender were established by Doty to aid in the diagnosis of Parkinson’s disease . For other neurodegenerative disorders these criteria are not (yet) available.
LAS3BS00, LAS3BS01, LAS3BS02, LASMBS00, LASMBS01, LASMBS02 (during the medical interview the test consisted of 4 booklets each containing 10 different smell-patches).
LAS3BS00, LAS3BS01, LAS3BS02, LASMBS00, LASMBS01, LASMBS02
Availability of information per wave1:
1 More information about the LASA data collection waves is available here.
* 2B=baseline second cohort;
3B=baseline third cohort;
MB=migrants: baseline first cohort
Ma=data collected in medical interview
Previous use in LASA
Olfaction has not been previously used.
- Attems, J., L. Walker, and K.A. Jellinger, Olfaction and Aging: A Mini-Review. Gerontology, 2015. 61(6): p. 485-90.
- Toussaint, N., et al., Loss of olfactory function and nutritional status in vital older adults and geriatric patients. Chem Senses, 2015. 40(3): p. 197-203.
- Doty, R.L., Olfactory dysfunction in Parkinson disease. Nat Rev Neurol, 2012. 8(6): p. 329-39.
- Ponsen, M.M., et al., Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol, 2004. 56(2): p. 173-81.
- Ross, G.W., et al., Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol, 2008. 63(2): p. 167-73.
- Doty, R.L., P. Shaman, and M. Dann, Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav, 1984. 32(3): p. 489-502.
- Doty, R.L., S.M. Bromley, and M.B. Stern, Olfactory testing as an aid in the diagnosis of Parkinson's disease: development of optimal discrimination criteria. Neurodegeneration, 1995. 4(1): p. 93-7.